Article

Painters in chromatin: a unified quantitative framework to systematically characterize epigenome regulation and memory

2022-03-31

Abstract excerpt

In eukaryotes, many stable and heritable phenotypes arise from the same DNA sequence, owing to epigenetic regulatory mechanisms relying on the molecular cooperativity of “reader-writer” enzymes. In this work, we focus on the fundamental, generic mechanisms behind the epigenome memory encoded by post-translational modifications of histone tails. Based on experimental knowledge, we introduce a unified modeling frame...

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Literature Corpus work: affb9636-fd3b-512a-a37d-f3fda86eeaff
DOI: 10.1101/2022.03.30.486379

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