Article

Memory Regulatory T Cells Reprogram into Protective Tfh-like Effectors in Recurrent Malaria

2025-10-15

Abstract excerpt

Although people living in malaria-endemic areas experience repeated infections with Plasmodium , the role of regulatory T cells (Tregs) in recurrent malaria remains poorly understood. During a primary infection with Plasmodium , Tregs suppress protective immunity by inhibiting germinal center (GC) reactions, thereby impeding the control of parasitemia. In contrast, we demonstrate here that memory Tregs (mTregs)...

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Literature Corpus work: ef59af03-f92e-5fd0-a517-ec77479c051b
DOI: 10.1101/2025.10.15.682462

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