Article

Targeting type I regulatory T cells to enhance anti-parasitic T helper 1 and T follicular helper cell responses in human malaria

2026-06-05

Abstract excerpt

<title>Abstract</title> Type I interferon (IFN) signalling promotes development of type 1 regulatory (Tr1) CD4+ T cells, which suppress inflammation but may limit protective immunity in malaria by constraining effector Th1 cells and antibody-promoting T follicular helper (Tfh) cells. We tested whether transiently blocking IFN-driven JAK/STAT signalling with ruxolitinib would reduce Tr1 cell development and enh...

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Literature Corpus work: af12f2f8-a721-56dc-bfd5-02fc15ca3cde
DOI: 10.21203/rs.3.rs-8803488/v1

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