Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype.

PLoS pathogens - 1 Apr 2021

Guha Rajan, Mathioudaki Anna, Doumbo Safiatou, Doumtabe Didier, Skinner Jeff, Arora Gunjan, Siddiqui Shafiuddin, Li Shanping, Kayentao Kassoum, Ongoiba Aissata, Zaugg Judith, Traore Boubacar, Crompton Peter D

Abstract excerpt

In malaria-naïve children and adults, Plasmodium falciparum-infected red blood cells (Pf-iRBCs) trigger fever and other symptoms of systemic inflammation. However, in endemic areas where individuals experience repeated Pf infections over many years, the risk of Pf-iRBC-triggered inflammatory symptoms decreases with cumulative Pf exposure. The molecular mechanisms underlying these clinical observations remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokines
Share to Erythrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Macrophages

Share to Malaria

Share to Malaria, Falciparum

Share to Monocytes

Share to Plasmodium falciparum

Source

Open in PubMed Open full text

Identifiers

PMID: 33822828
DOI: 10.1371/journal.ppat.1009430
PMCID: PMC8023468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype.PMID 33822828Read ↗

<i>Plasmodium falciparum</i> malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotypeSemantic proximity Read ↗

Epigenetic and transcriptional regulation of cytokine production by Plasmodium falciparum-exposed monocytesSemantic proximity Read ↗

Disease Tolerance Acquired Through Repeated <i>Plasmodium</i> Infection Involves Epigenetic Reprogramming of Innate Immune CellsSemantic proximity Read ↗

Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malariaSemantic proximity Read ↗

scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malariaSemantic proximity Read ↗

Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infectionSemantic proximity Read ↗

Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malariaSemantic proximity Read ↗

Molecular and Epigenetics Mechanisms for the Immune Control of Plasmodium Parasites Infection: A Comprehensive ReviewSemantic proximity Read ↗

Genetics of Malaria Inflammatory Responses: A Pathogenesis PerspectiveSemantic proximity Read ↗

Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsetsSemantic proximity Read ↗

Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent periodSemantic proximity Read ↗

Common and Divergent Immune Response Signaling Pathways Discovered in Peripheral Blood Mononuclear Cell Gene Expression Patterns in Presymptomatic and Clinically Apparent MalariaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.