Article

Cytotoxic T cells are silenced to induce disease tolerance in human malaria

2021-08-24

Abstract excerpt

Immunity to severe malaria is acquired quickly, operates independently of pathogen load and represents a highly effective form of disease tolerance. The mechanism that underpins tolerance remains unknown. We developed a human re-challenge model of falciparum malaria in which healthy adult volunteers were infected three times over a 12 month period to track the development of disease tolerance in real-time. We foun...

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Identifiers and source

Literature Corpus work: 31496178-11ad-500d-b560-1394565a42f0
DOI: 10.1101/2021.08.19.21262298

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