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Targeting type I regulatory T cells to enhance anti-parasitic T helper 1 and T follicular helper cell responses in human malaria

2025-04-11

Abstract excerpt

Type I interferon (IFN) signalling promotes development of type 1 regulatory (Tr1) CD4 + T cells, which suppress inflammation but may limit protective immunity in malaria by constraining effector Th1 cells and antibody-promoting T follicular helper (Tfh) cells. We tested whether transiently blocking IFN-driven JAK/STAT signalling with ruxolitinib would reduce Tr1 cell development and enhance protective Th1 and Tf...

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Identifiers and source

Literature Corpus work
84f82e1d-d3be-5dfc-988c-dc60e0c31f6f
DOI
10.1101/2025.04.09.25325416
Open publication

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Targeting type I regulatory T cells to enhance anti-parasitic T helper 1 and T follicular helper cell responses in human malariaDOI 10.1101/2025.04.09.25325416
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