Article

Colorectal cancer is associated with the presence of cancer driver mutations in normal colon

2021-10-14

Abstract excerpt

<h4>ABSTRACT</h4> While somatic mutations in colorectal cancer (CRC) are well characterized, little is known about the accumulation of cancer mutations in the normal colon prior to cancer. Here we have developed and applied an ultra-sensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mutation detection at extremely low frequency (<0.001) in normal colon from patients with and wi...

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Literature Corpus work: 7d3323be-fa47-59ef-aa1f-e09bb6f1d822
DOI: 10.1101/2021.10.11.21264780

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