Article
Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon.
Cancer research - 15 Apr 2022
Matas Julia, Kohrn Brendan, Fredrickson Jeanne, Carter Kelly, Yu Ming, Wang Ting, Gui Xianyong, Soussi Thierry, Moreno Victor, Grady William M, Peinado Miguel A, Risques Rosa Ana
Abstract excerpt
Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of cancer mutations in the normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mutation detection at extremely low frequency (<0.001) in normal colon from patients with and without colorectal...
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