Article

Expanded Genetic Alphabet Increases Structural and Chemical Diversity of Six-Letter DNA for High-Affinity Protein-Targeting Aptamers

2025-04-16

Abstract excerpt

<title>Abstract</title> <p>The expansion of the genetic alphabet through unnatural base pairs (UBPs) enables novel biotechnologies to create biopolymers with enhanced informational and functional properties. Hydrophobic UBPs, such as Ds − Px and Ds − Pa′, exhibit high fidelity during PCR amplification to enable the generation of UB-containing DNA aptamers (XenoAptamers) with exceptional affinity and specificity f...

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Literature Corpus work: ef05855f-b9f4-5554-8d58-e2994d009c25
DOI: 10.21203/rs.3.rs-6296070/v1

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Expanded Genetic Alphabet Increases Structural and Chemical Diversity of Six-Letter DNA for High-Affinity Protein-Targeting AptamersDOI 10.21203/rs.3.rs-6296070/v1Read

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