Article

Fluorogenic Aptamer Optimizations on a Massively Parallel Sequencing Platform

2024-07-10

Abstract excerpt

F luorogenic ap tamers (FAPs) have become an increasingly important tool in cellular sensing and pathogen diagnostics. However, fine-tuning FAPs for enhanced performance remains challenging even with the structural details provided by X-ray crystallography. Here we present a novel approach to optimize a DNA-based FAP (D-FAP), Lettuce, on repurposed Illumina next-generation sequencing (NGS) chips. When substitutin...

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Literature Corpus work: 2aa0c432-d2a4-57ff-aee4-a02f9cb74f85
DOI: 10.1101/2024.07.07.602435

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