Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatial- and Valence-Matched Neutralizing DNA Nanostructure Blocks Wild-Type SARS-CoV-2 and Omicron Variant Infection

8 Sept 2022

Abstract excerpt

Natural ligand-receptor interactions that play pivotal roles in biological events are ideal models for design and assembly of artificial recognition molecules. Herein, aiming at the structural characteristics of the spike trimer and infection mechanism of SARS-CoV-2, we have designed a DNA framework-guided spatial-patterned neutralizing aptamer trimer for SARS-CoV-2 neutralization. The ∼5.8 nm tetrahedral DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to SARS-CoV-2 and COVID-19 Research
Share to SARS-CoV-2 detection and testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36073793
DOI: 10.1021/acsnano.2c06803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatial- and Valence-Matched Neutralizing DNA Nanostructure Blocks Wild-Type SARS-CoV-2 and Omicron Variant InfectionPMID 36073793Read ↗

Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape.Semantic proximity Read ↗

Respiratory mucosal administration of DNA aptamer nanomaterials protects against antigenically diverse SARS-CoV-2 variantsSemantic proximity Read ↗

Engineering Versatile Two-Dimensional Nanobody-Origami Architectures for Enhanced Antiviral ActivitySemantic proximity Read ↗

DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2Semantic proximity Read ↗

Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibitionSemantic proximity Read ↗

A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2Semantic proximity Read ↗

Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistanceSemantic proximity Read ↗

Fighting Mutations with Mutations: Evolutionarily Adapting a DNA Aptamer for High‐Affinity Recognition of Mutated Spike Proteins of SARS‐CoV‐2Semantic proximity Read ↗

Binding mechanism of neutralizing Nanobodies targeting SARS-CoV-2 Spike GlycoproteinSemantic proximity Read ↗

Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agentsSemantic proximity Read ↗

A High-Throughput Platform for Rapid Adaptation of DNA Aptamers to SARS-CoV-2 EvolutionSemantic proximity Read ↗

Elucidating the molecular docking and binding dynamics of aptamers with spike proteins across SARS-CoV-2 variants of concernSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.