Over-Represented DNA Libraries Containing Two Hydrophobic (Het)aryl-Linked Nucleotides for Expedient Single-Round Selection of a Specific Aptamer Targeting Human Insulin Receptor

Abstract excerpt

<title>Abstract</title> <p> Discovery of functional nucleic acid ligands and catalytic motifs from a vast sequence space of randomized libraries is mostly based on time-consuming and demanding iterative rounds of <italic>in vitro</italic> selection. Here, we present a streamlined method for rapid identification of nucleobase-modified aptamers in a single selection round by combining chemically modified over-re...

Topics

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• Antigens, Viral
• Aptamers, Nucleotide
• Chemical Synthesis and Analysis
• DEAD Box Protein 58
• Monoclonal and Polyclonal Antibodies Research
• RNA and protein synthesis mechanisms
• RNA Research and Splicing
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

d8e7e5a1-0f64-5e8c-b56d-aa4476807e84

DOI

10.21203/rs.3.rs-7946390/v1