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Article

Unique Thermal Stability of Unnatural Hydrophobic Ds Bases in Double-Stranded DNAs.

ACS synthetic biology - 20 Oct 2017

Kimoto Michiko, Hirao Ichiro

Abstract excerpt

Genetic alphabet expansion technology, the introduction of unnatural bases or base pairs into replicable DNA, has rapidly advanced as a new synthetic biology area. A hydrophobic unnatural base pair between 7-(2-thienyl)imidazo[4,5-b]pyridine (Ds) and 2-nitro-4-propynylpyrrole (Px) exhibited high fidelity as a third base pair in PCR. SELEX methods using the Ds-Px pair enabled high-affinity DNA aptamer generation,...

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Share to Aptamers, Nucleotide
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrophobic and Hydrophilic Interactions

Share to Polymorphism, Single Nucleotide

Share to Real-Time Polymerase Chain Reaction

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Source

Identifiers

PMID: 28704034
DOI: 10.1021/acssynbio.7b00165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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