Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification.

Nucleic acids research - 18 Nov 2021

Matsunaga Ken-Ichiro, Kimoto Michiko, Lim Vanessa Weixun, Tan Hui Pen, Wong Yu Qian, Sun William, Vasoo Shawn, Leo Yee Sin, Hirao Ichiro

Abstract excerpt

Genetic alphabet expansion of DNA by introducing unnatural bases (UBs), as a fifth letter, dramatically augments the affinities of DNA aptamers that bind to target proteins. To determine whether UB-containing DNA (UB-DNA) aptamers obtained by affinity selection could spontaneously achieve high specificity, we have generated a series of UB-DNA aptamers (KD: 27-182 pM) targeting each of four dengue non-structural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to Aptamers, Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dengue

Share to Molecular Diagnostic Techniques

Share to Mutation

Share to Protein Binding

Share to Serogroup

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34169309
DOI: 10.1093/nar/gkab515
PMCID: PMC8599795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification.PMID 34169309Read ↗

Expanded Genetic Alphabet Increases Structural and Chemical Diversity of Six-Letter DNA for High-Affinity Protein-Targeting AptamersSemantic proximity Read ↗

A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of ConcernSemantic proximity Read ↗

Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library.Semantic proximity Read ↗

Development of ssDNA Aptamers for Diagnosis and Inhibition of the Highly Pathogenic Avian Influenza Virus Subtype H5N1Semantic proximity Read ↗

A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of ConcernSemantic proximity Read ↗

Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibitionSemantic proximity Read ↗

DNA aptamer selection and construction of an aptasensor based on graphene FETs for Zika virus NS1 protein detectionSemantic proximity Read ↗

The Diagnostic Potential of RNA Aptamers against the NS1 Protein of Dengue Virus Serotype 2Semantic proximity Read ↗

Novel system for detecting SARS coronavirus nucleocapsid protein using an ssDNA aptamerSemantic proximity Read ↗

Aptamer based diagnosis of crimean-congo hemorrhagic fever from clinical specimensSemantic proximity Read ↗

A 2′FY-RNA Motif Defines an Aptamer for Ebolavirus Secreted ProteinSemantic proximity Read ↗

Nucleic Acid-Based Aptamers: Applications, Development and Clinical TrialsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.