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Selection and Characterization of DNA Aptamers Targeting All Four Serotypes of Dengue Viruses

25 Jun 2015

Abstract excerpt

Dengue viruses (DENVs) are members of Flaviviridae family, which are associated with human disease. The envelope (E) protein plays an important role in viral infection. However, there is no effective antibody for clinical treatment due to antibody dependent enhancement of infection. In this study, using Systematic Evolution of Ligands by Exponential Enrichment (SELEX), we demonstrated the first aptamer (S15) that...

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PMID: 26110785
DOI: 10.1371/journal.pone.0131240

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