Article

<i>CDK13</i> Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

2019-11-05

Abstract excerpt

Transcriptional Cyclin Dependent Kinases modulate RNA Polymerase II function to impact gene expression. Here, we show that CDK13 is mutated in 4% of patient melanomas and mutation or downregulation is associated with poor overall survival. Mutant CDK13 lacks kinase activity and overexpression in zebrafish leads to accelerated melanoma. CDK13 mutant fish and human melanomas accumulate prematurely terminated RNAs t...

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Identifiers and source

Literature Corpus work: ef0212bc-8e62-553f-a5aa-ae1ba4e33ebf
DOI: 10.1101/824193

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