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Article

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish.

PLoS genetics - 1 Aug 2017

Scahill Catherine M, Digby Zsofia, Sealy Ian M, Wojciechowska Sonia, White Richard J, Collins John E, Stemple Derek L, Bartke Till, Mathers Marie E, Patton E Elizabeth, Busch-Nentwich Elisabeth M

Abstract excerpt

KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanomas at a high frequency. Fish homozygous for two independent premature stop codon alleles show reduced growth and...

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Identifiers

PMID: 28806732
DOI: 10.1371/journal.pgen.1006959
PMCID: PMC5570503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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