Article

Distinct effects of CDK8 module subunits on cellular growth and proliferation in <i>Drosophila</i>

2024-05-03

Abstract excerpt

The Mediator complex, composed of about 30 conserved subunits, plays a pivotal role in facilitating RNA polymerase II-dependent transcription in eukaryotes. Within this complex, the CDK8 kinase module (CKM), comprising Med12, Med13, CDK8, and CycC (Cyclin C), serves as a dissociable subcomplex that modulates the activity of the small Mediator complex. Genetic studies in Drosophila have revealed distinct phenotype...

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Identifiers and source

Literature Corpus work: 905185b4-ef31-5c67-b0c6-4735e577aae6
DOI: 10.1101/2024.04.30.591924

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