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Article

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation.

Developmental cell - 10 Aug 2020

Johansson Jeanette A, Marie Kerrie L, Lu Yuting, Brombin Alessandro, Santoriello Cristina, Zeng Zhiqiang, Zich Judith, Gautier Philippe, von Kriegsheim Alex, Brunsdon Hannah, Wheeler Ann P, Dreger Marcel, Houston Douglas R, Dooley Christopher M, Sims Andrew H, Busch-Nentwich Elisabeth M, Zon Leonard I, Illingworth Robert S, Patton E Elizabeth

Abstract excerpt

Melanocytes, replenished throughout life by melanocyte stem cells (MSCs), play a critical role in pigmentation and melanoma. Here, we reveal a function for the metastasis-associated phosphatase of regenerating liver 3 (PRL3) in MSC regeneration. We show that PRL3 binds to the RNA helicase DDX21, thereby restricting productive transcription by RNAPII at master transcription factor (MITF)-regulated endolysosomal...

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Share to DEAD-box RNA Helicases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32652076
DOI: 10.1016/j.devcel.2020.06.013
PMCID: PMC7435699

Genes

DDX21
MITF
MSC

Provenance

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