Article

Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA

2025-01-14

Abstract excerpt

Endogenous retroviral (ERV) RNA is highly expressed in cancer, although the molecular causes and consequences remain unknown. We found that ZC3H18 (Z18), a component of multiple nuclear RNA surveillance complexes, has recurrent truncating mutations in cancer. We show that Z18 trunc mutations are oncogenic and that Z18 plays an evolutionarily conserved role in nuclear RNA surveillance of ERV RNA. In zebrafish, Z18...

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Literature Corpus work: a6ecdad0-04f9-52c4-94d2-f79fee1680c5
DOI: 10.1101/2025.01.10.632423

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