Article

Macrophage metabolic regulation by phosphoglucomutase 1 shapes the host immune response in pneumococcal meningitis

2025-12-22

Abstract excerpt

<title>Abstract</title> <p> Pneumococcal meningitis remains a life-threatening disease despite antibiotic and anti-inflammatory therapy, with unfavourable outcome driven by excessive inflammation and impaired bacterial clearance. Host genetic variation influences disease outcome in pneumococcal meningitis, though the underlaying mechanisms remain unclear. In a genome-wide association study, we identified the sin...

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Literature Corpus work: eeedc671-1199-50d5-8c80-53c56141d0eb
DOI: 10.21203/rs.3.rs-8319354/v1

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