Article

GPR17 as a Macrophage Sensor for Gram-Positive Peptidoglycan: Implications for Invasive Bacterial Infection

2026-04-13

Abstract excerpt

<title>Abstract</title> <p>Invasive gram-positive infections, including necrotizing fasciitis, streptococcal toxic shock syndrome, and staphylococcal sepsis, disproportionately strike otherwise healthy individuals, implying a dominant role for host genetic susceptibility in innate bacterial surveillance. Here we present transcriptomic, structural pharmacophore, and molecular docking evidence supporting GPR17, a G...

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Literature Corpus work: 6cfbcf04-c8a1-5774-99e7-b86e4c268348
DOI: 10.21203/rs.3.rs-8968070/v2

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