Article

The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality

2024-05-28

Abstract excerpt

<h4> Abstract </h4> <h4>Background</h4> Pneumococcal meningitis (PM) has persistently poor clinical outcomes, especially in sub- Saharan Africa. To better characterise the inflammatory response and identify factors associated with mortality we compared paired peripheral blood and cerebrospinal fluid (CSF) transcriptomes before the initiation of antibiotics in Malawian adults with proven PM. <h4>Results</h4> Bl...

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Literature Corpus work: 63af5d0d-d2ac-538b-bb64-1beff0dccc64
DOI: 10.1101/2024.05.24.592913

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