Article

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

2018-12-07

Abstract excerpt

<h4>Background</h4> Improving outcomes from pneumococcal meningitis (PM), particularly in populations with high HIV prevalence, requires better understanding of host inflammatory responses to infection. <h4>Methods</h4> We compared the transcriptome in pre-antibiotic cerebrospinal fluid (CSF) and blood from Malawian adults with PM using RNA sequencing. We used network analyses and cellular/process deconvolution...

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Literature Corpus work: 98103f00-0b3b-5171-ab0c-f83256566c7d
DOI: 10.1101/490045

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