Article

Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in sepsis, modulating disease

2025-05-26

Abstract excerpt

<title>Abstract</title> <p> Sepsis is a heterogeneous clinical syndrome with a high mortality rate and personalised stratification strategies are proposed as essential to successful targeted therapeutics. Here, we characterise genetic variation that modulates <italic>MTOR</italic> , a critical regulator of metabolism and immune responses in sepsis. The effects are highly context specific, involving a regulator...

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Literature Corpus work: 9ba56361-2f5e-5f28-acdf-4d97c7b795d4
DOI: 10.21203/rs.3.rs-6457289/v1

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