Article

Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathy

2022-05-18

Abstract excerpt

<h4>ABSTRACT</h4> The potential use of the D2. mdx mouse (the mdx mutation on the DBA/2J genetic background) as a preclinical model of the cardiac aspects of Duchenne muscular dystrophy (DMD) has been criticized based on speculation that the DBA/2J genetic background displays an inherent hypertrophic cardiomyopathy phenotype. Accordingly, the goal of the current study was to further examine the cardiac status o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eee5bcac-7e7c-5079-81b0-f4aeef44f99a
DOI: 10.1101/2022.05.16.492163

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathyDOI 10.1101/2022.05.16.492163Read

The D2- <i>mdx</i> mouse as a preclinical model for Duchenne muscular dystrophy: a natural history study across two independent sitesSemantic proximity Read

Effect of genetic background on the dystrophic phenotype in mdx mice.Semantic proximity Read

A Murine Hypertrophic Cardiomyopathy Model: The DBA/2J Strain.Semantic proximity Read

MYH6-Cre Insertion Accelerates Cardiac Phenotype in Dystrophic D2-mdx Mice.Semantic proximity Read

Functional cardiac consequences of β-adrenergic stress-induced injury in the <i>mdx</i> mouse model of Duchenne muscular dystrophySemantic proximity Read

Humanization of the mdx Mouse Phenotype for Duchenne Muscular Dystrophy Modeling: A Metabolic Perspective.Semantic proximity Read

Genetic background affects properties of satellite cells and mdx phenotypes.Semantic proximity Read

A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic Dmd deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathySemantic proximity Read

Current Translational Research and Murine Models For Duchenne Muscular DystrophySemantic proximity Read

Models of dilated cardiomyopathy in the mouse and the hamster.Semantic proximity Read

Diabetes in mice with monogenic obesity: the db/db mouse and its use in the study of cardiac consequences.Semantic proximity Read

The BALB/c.mdx62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy.Semantic proximity Read