Article
Diabetes in mice with monogenic obesity: the db/db mouse and its use in the study of cardiac consequences.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Belke Darrell D, Severson David L
Abstract excerpt
The leptin receptor deficient db/db mouse has served as a rodent model for obesity and type 2 diabetes for more than 40 years. Diabetic features in db/db mice follow an age-dependent progression, with early insulin resistance followed by an insulin secretory defect resulting in profound hyperglycemia. Diabetic db/db mice have been utilized to assess the cardiac consequences of diabetes, specifically evidence for...
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