Article
The BALB/c.mdx62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy.
Disease models & mechanisms - 1 Apr 2024
Swiderski Kristy, Chan Audrey S, Herold Marco J, Kueh Andrew J, Chung Jin D, Hardee Justin P, Trieu Jennifer, Chee Annabel, Naim Timur, Gregorevic Paul, Lynch Gordon S
Abstract excerpt
Duchenne muscular dystrophy (DMD) is a devastating monogenic skeletal muscle-wasting disorder. Although many pharmacological and genetic interventions have been reported in preclinical studies, few have progressed to clinical trials with meaningful benefit. Identifying therapeutic potential can be limited by availability of suitable preclinical mouse models. More rigorous testing across models with varied...
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