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Article

A Murine Hypertrophic Cardiomyopathy Model: The DBA/2J Strain.

PloS one - 1 Jan 2015

Zhao Wenyuan, Zhao Tieqiang, Chen Yuanjian, Zhao Fengbo, Gu Qingqing, Williams Robert W, Bhattacharya Syamal K, Lu Lu, Sun Yao

Abstract excerpt

Familial hypertrophic cardiomyopathy (HCM) is attributed to mutations in genes that encode for the sarcomere proteins, especially Mybpc3 and Myh7. Genotype-phenotype correlation studies show significant variability in HCM phenotypes among affected individuals with identical causal mutations. Morphological changes and clinical expression of HCM are the result of interactions with modifier genes. With the...

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Source

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Identifiers

PMID: 26241864
DOI: 10.1371/journal.pone.0133132
PMCID: PMC4524617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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