Article
Effect of genetic background on the dystrophic phenotype in mdx mice.
Human molecular genetics - 1 Jan 2016
Coley William D, Bogdanik Laurent, Vila Maria Candida, Yu Qing, Van Der Meulen Jack H, Rayavarapu Sree, Novak James S, Nearing Marie, Quinn James L, Saunders Allison, Dolan Connor, Andrews Whitney, Lammert Catherine, Austin Andrew, Partridge Terence A, Cox Gregory A, Lutz Cathleen, Nagaraju Kanneboyina
Abstract excerpt
Genetic background significantly affects phenotype in multiple mouse models of human diseases, including muscular dystrophy. This phenotypic variability is partly attributed to genetic modifiers that regulate the disease process. Studies have demonstrated that introduction of the γ-sarcoglycan-null allele onto the DBA/2J background confers a more severe muscular dystrophy phenotype than the original strain,...
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