Article
Models of dilated cardiomyopathy in the mouse and the hamster.
Current opinion in cardiology - 1 May 2000
Ikeda Y, Ross J
Abstract excerpt
Dilated cardiomyopathy (DCM) is a heart muscle disorder characterized by atrial and ventricular dilation often with relative wall thinning, severe systolic and diastolic ventricular dysfunction, and frequent findings of heart failure. Using genetically engineered mice, a number of studies have attempted to determine the role of specific genes, as well as to mimic the phenotype of human DCM. Naturally occurring...
Topics
- Animals
- Calcium Channels
- Cardiomyopathy, Dilated
- Cricetinae
- Cytoskeleton
- Disease Models, Animal
- GTP-Binding Protein Regulators
- Heart Failure
- Humans
- Mesocricetus
- Mice
- Mice, Transgenic
- Mutation
- Sarcomeres
- Signal Transduction
- Transcription Factors
- Ventricular Dysfunction