Article

Blood vessel organoids generated by base editing and harboring single nucleotide variation in Notch3 effectively recapitulate CADASIL-related pathogenesis

2024-01-23

Abstract excerpt

<title>Abstract</title> <p>Human blood vessel organoids (hBVOs) offer a promising platform for investigating vascular diseases and identifying therapeutic targets. In this study, we focused on in vitro modeling and therapeutic target finding of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary stroke disorder caused by mutation...

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Literature Corpus work: eee1b09c-7038-582b-994d-fcc2f379e669
DOI: 10.21203/rs.3.rs-3632879/v1

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