Article

Cellular and Molecular Characterization of CADASIL Using In Vitro Models of Vascular Smooth Muscle Cells and Blood Vessel Organoids

2023-09-21

Abstract excerpt

<title>Abstract</title> Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common inherited form of stroke, characterized by a NOTCH3 mutation on chromosome 19. Despite many genetic and functional studies, the exact mechanisms and pathologies have not been fully elucidated. Herein, the cellular and molecular characteristics of vascular smooth muscle...

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Literature Corpus work: 63950979-4b97-5f69-872e-dffb21396047
DOI: 10.21203/rs.3.rs-3137138/v1

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