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Article

Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases.

The American journal of pathology - 1 Nov 2021

Schoemaker Dorothee, Arboleda-Velasquez Joseph F

Abstract excerpt

Mutations in the NOTCH3 gene can lead to small-vessel disease in humans, including the well-characterized cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a condition caused by NOTCH3 mutations altering the number of cysteine residues in the extracellular domain of Notch3. Growing evidence indicates that other types of mutations in NOTCH3, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebrovascular and genetic disorders

Share to Metalloenzymes and iron-sulfur proteins

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Share to Protein Aggregation, Pathological

Share to Receptor, Notch3

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Source

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Identifiers

PMID: 33895122
DOI: 10.1016/j.ajpath.2021.03.015
PMCID: PMC8647433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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