Article
Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures.
Stem cell reports - 12 Nov 2019
Kelleher Joseph, Dickinson Adam, Cain Stuart, Hu Yanhua, Bates Nicola, Harvey Adam, Ren Jianzhen, Zhang Wenjun, Moreton Fiona C, Muir Keith W, Ward Christopher, Touyz Rhian M, Sharma Pankaj, Xu Qingbo, Kimber Susan J, Wang Tao
Abstract excerpt
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common form of genetic stroke and vascular dementia syndrome resulting from mutations in NOTCH3. To elucidate molecular mechanisms of the condition and identify drug targets, we established a patient-specific induced pluripotent stem cell (iPSC) model and demonstrated for the first time a failure of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.