Article

Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease CADASIL

2023-04-26

Abstract excerpt

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common genetic small vessel disease caused by variants in the NOTCH3 gene. Patients with CADASIL experience recurrent strokes, developing into cognitive defect and vascular dementia. CADASIL is a late-onset vascular condition, but migraine and brain MRI lesions appear in CADASIL patients as early as th...

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Literature Corpus work: 36c39110-239c-5f46-8293-90a0607da9f9
DOI: 10.1101/2023.04.26.538393

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