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Article

NOTCH3 Mutations in CADASIL: a multicellular perspective on neurodegeneration.

Cell communication and signaling : CCS - 3 Mar 2026

Lee Jolene Wei Ling, Ng Adeline Su Lyn, Tan Eng-King, Zeng Li

Abstract excerpt

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary cerebral small-vessel disease caused by NOTCH3 cysteine-altering mutations. Clinical evidence, including early-onset migraines, psychiatric symptoms, and diffuse white-matter hyperintensities preceding strokes, suggests a nonvascular pathology. NOTCH3 is broadly expressed in neural progenitors,...

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Source

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Identifiers

PMID: 41776534
DOI: 10.1186/s12964-026-02764-9
PMCID: PMC13088557

Genes

NOTCH3
AQP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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