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Selective vulnerability of cerebral vasculature to <i>NOTCH3</i> variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor

2025-06-03

Abstract excerpt

NOTCH3 variants cause CADASIL the most common genetic form of small vessel disease (SVD) and vascular dementia (VaD) and increase the stroke and SVD/VaD risk. CADASIL is a systemic vasculopathy but predominantly manifests in the brain. The molecular mechanisms of CADASIL remain largely unclear with no specific available treatments. NOTCH3 is primarily expressed in vascular smooth muscle cells (VSMCs). Using human...

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Literature Corpus work
d317ec2f-d599-5b01-a28e-00242b07ce8a
DOI
10.1101/2025.05.30.656914
Open publication

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Selective vulnerability of cerebral vasculature to <i>NOTCH3</i> variants in small vessel disease and rescue by phosphodiesterase-5 inhibitorDOI 10.1101/2025.05.30.656914
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