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Article

Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.

Science advances - 3 Apr 2026

Zhao Xiangjun, Yu Chaowen, Adamson Antony, Zhao Aite, Zhou Huiyu, Sharma Pankaj, Wang Tao

Abstract excerpt

NOTCH3 variants cause CADASIL (cerebral autosomal dominant arteriopathy and subcortical infarcts and leukoencephalopathy), the most common monogenetic form of small vessel disease (SVD) and vascular dementia (VaD). The molecular mechanisms driving CADASIL pathogenesis remain poorly understood, and no specific treatments are currently available. NOTCH3 is mainly expressed in vascular smooth muscle cells (VSMCs)...

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Share to CADASIL
Share to NOTCH3 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Muscle, Smooth, Vascular

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Share to Myocytes, Smooth Muscle

Share to Receptor, Notch3

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Source

Open in PubMed Open full text

Identifiers

PMID: 41931622
DOI: 10.1126/sciadv.aeb1134
PMCID: PMC13048245

Genes

NOTCH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.PMID 41931622Read ↗

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