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CADASIL from Bench to Bedside: Disease Models and Novel Therapeutic Approaches

19 Jan 2021

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic disease caused by NOTCH3 mutations and characterized by typical clinical, neuroradiological, and pathological features. NOTCH3 belongs to a family of highly conserved transmembrane receptors rich of epidermal growth factor repeats, mostly expressed in vascular smooth muscle cells and pericytes,...

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PMID: 33464533
DOI: 10.1007/s12035-021-02282-4

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