Article

From aging to Alzheimer’s disease: concordant brain DNA methylation changes in late life

2025-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Aging is the strongest risk factor for Alzheimer’s disease (AD), yet the molecular mechanisms linking aging to AD remain poorly understood. DNA methylation (DNAm) is an epigenetic modification that plays a critical role in gene regulation and has been implicated in both aging and AD. In this study, we performed a meta-analysis of DNAm profiles in the prefrontal cortex using two large, independent...

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Literature Corpus work: 7d78b932-aaf2-5513-830f-7f003499613b
DOI: 10.1101/2025.06.17.25329345

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