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5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Diagnostic Biomarkers for Late-Onset Alzheimer’s Disease

2021-08-06

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>5-Hydroxymethylcytosine (5hmC) is an epigenetic DNA modification that is highly abundant in nervous system. It has been reported that 5hmC is significant associated with Alzheimer’s disease (AD). Changes in 5hmC signatures can be detected in circulating cell-free DNA (cfDNA), which has shown potential as a non-invasive liquid biopsy material. However, there is n...

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Literature Corpus work: 69d4f695-aa8d-5894-a759-b153feca1dd4
DOI: 10.21203/rs.3.rs-774460/v1

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