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Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology

22 Mar 2025

Abstract excerpt

5-hydroxymethylcytosine, also known as the sixth DNA base of the genome, plays an important role in brain aging and neurological disorders such as Alzheimer's disease. However, little is known about its genome-wide distribution and its association with Alzheimer's disease pathology. Here, we report a genome-wide profiling of 5-hydroxymethylcytosine in 1079 autopsied brains (dorsolateral prefrontal cortex) of...

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PMID: 40121201
DOI: 10.1038/s41467-025-58159-w

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