Article
Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways.
Current biology : CB - 9 May 2016
Spoida Katharina, Eickelbeck Dennis, Karapinar Raziye, Eckhardt Tobias, Mark Melanie D, Jancke Dirk, Ehinger Benedikt Valerian, König Peter, Dalkara Deniz, Herlitze Stefan, Masseck Olivia A
Abstract excerpt
G-protein-coupled receptors (GPCRs) represent the major protein family for cellular modulation in mammals. Therefore, various strategies have been developed to analyze the function of GPCRs involving pharmaco- and optogenetic approaches [1, 2]. However, a tool that combines precise control of the activation and deactivation of GPCR pathways and/or neuronal firing with limited phototoxicity is still missing. We...
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