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Article

Robotic manipulation of cardiomyocytes to identify gap junction modifiers for arrhythmogenic cardiomyopathy.

Science robotics - 23 Oct 2024

Dou Wenkun, Shan Guanqiao, Zhao Qili, Malhi Manpreet, Jiang Aojun, Zhang Zhuoran, González-Guerra Andrés, Fu Shaojie, Law Junhui, Hamilton Robert M, Bernal Juan A, Liu Xinyu, Sun Yu, Maynes Jason T

Abstract excerpt

Arrhythmogenic cardiomyopathy (ACM) is a leading cause of sudden cardiac death among young adults. Aberrant gap junction remodeling has been linked to disease-causative mutations in plakophilin-2 (PKP2). Although gap junctions are a key therapeutic target, measurement of gap junction function in preclinical disease models is technically challenging. To quantify gap junction function with high precision and high...

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Identifiers

PMID: 39441897
DOI: 10.1126/scirobotics.adm8233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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