Article

Extracellular signalling and stem cell self-renewal

2017-01-01

Abstract excerpt

In preimplantation mouse embryos, signalling and gene regulatory networks cooperate to determine lineage segregation, and modulating signalling in vitro allows for stem cell populations to be established from these lineages. Fibroblast growth factor (FGF) signalling triggers the differentiation of primitive endoderm (PrE) cells fated to contribute to the yolk sac, while cells unreceptive to FGF form the epiblast (...

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Literature Corpus work: eeb557e8-c0bc-59d8-9824-32131d93d887
DOI: 10.21954/ou.ro.0000c596

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