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Article

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.

Nature cell biology - 1 Jun 2014

Boroviak Thorsten, Loos Remco, Bertone Paul, Smith Austin, Nichols Jennifer

Abstract excerpt

The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows that ESCs are distinct from early inner cell mass (ICM) and closely resemble pre-implantation epiblast. A characteristic feature of mouse ESCs is propagation without ERK signalling....

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Identifiers

PMID: 24859004
DOI: 10.1038/ncb2965
PMCID: PMC4878656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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