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Article

LIF supports primitive endoderm expansion during pre-implantation development.

Development (Cambridge, England) - 15 Oct 2015

Morgani Sophie M, Brickman Joshua M

Abstract excerpt

Embryonic stem cells (ESCs) are pluripotent cell lines that can be maintained indefinitely in an early developmental state. ESC culture conditions almost always require the cytokine LIF to maintain self-renewal. As ESCs are not homogeneous but contain multiple populations reminiscent of the blastocyst, identifying the target cells of LIF is necessary to understand the propagation of pluripotency. We recently...

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Source

Identifiers

PMID: 26395492
DOI: 10.1242/dev.125021

Genes

LIF
GATA6
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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