Article
Evolutionary scalpels for dissecting tumor ecosystems.
Biochimica et biophysica acta. Reviews on cancer - 1 Apr 2017
Rosenbloom Daniel I S, Camara Pablo G, Chu Tim, Rabadan Raul
Abstract excerpt
Amidst the growing literature on cancer genomics and intratumor heterogeneity, essential principles in evolutionary biology recur time and time again. Here we use these principles to guide the reader through major advances in cancer research, highlighting issues of "hit hard, hit early" treatment strategies, drug resistance, and metastasis. We distinguish between two frameworks for understanding heterogeneous...
Topics
- Adaptation, Physiological
- Animals
- Antineoplastic Agents
- Biomarkers, Tumor
- Cell Transformation, Neoplastic
- Drug Resistance, Neoplasm
- Evolution, Molecular
- Gene Expression Regulation, Neoplastic
- Genetic Fitness
- Genetic Predisposition to Disease