Article
Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer.
Cold Spring Harbor perspectives in medicine - 1 Sept 2017
Basanta David, Anderson Alexander R A
Abstract excerpt
The role of genetic mutations in cancer is indisputable: They are a key source of tumor heterogeneity and drive its evolution to malignancy. But, the success of these new mutant cells relies on their ability to disrupt the homeostasis that characterizes healthy tissues. Mutated clones unable to break free from intrinsic and extrinsic homeostatic controls will fail to establish a tumor. Here, we will discuss,...
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